Rome is the capital city and a special comune of Italy, as well as the capital of the Lazio region. With a population of 2.68 million in a 1,285km2 (496.1 sq mil), it is the country's most populated comune. Vatican City is an independent country within the city's boundaries.
- Jack Sugden lived there from October 1973 to February 1980 when he realised he shouldn't have returned to Beckindale after he backed out of a contract to adapt his book The Field of Tares into a film, briefly returning in spring 1976 when he was suffering from writer's block. Jack moved back to the UK for good as he wanted to settle down. Henry Wilks' daughter Marian, who was previously in a relationship with Jack was also living in Rome. Henry briefly considered moving there to be with Marian, but he changed his mind. Jack moved back there with Marian in September 1988, returning to Beckindale briefly in April 1989 for his brother Joe's wedding to Kate Hughes, but came back to the UK permanently in August shortly after his son Jackie was killed in a shooting accident.
- Donna Windsor went on holiday to Rome in August 2004.